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C18 Side Chain: Lysine at position 26 is acylated with an 18-carbon fatty diacid and a 2xOEG spacer, allowing for tighter binding to plasma albumin and reduced renal ltration

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This is considered to be the rate limiting step because it is dependent on the bioavailability of cysteine and the activity of GCL, the latter of which is modified by competitive inhibition by reduced glutathione (GSH) [3134]